Paullinia sorbilis (cupana) - Brazilian Cocoa
"CONSTITUENTS: Caffeine, Tannin, Volatile Oil, Saponin, Resin.
PREPARATIONS: Extractum Guaranae Fluidum. Fluid Extract Guarana. Dose: five to thirty minims. Extractum Guaranae, Extract of Guarana. Dose: three to ten grains. Specific Guarana, from one to fifteen minims.
Therapy: The fluid extract of this agent, given in doses of from ten to thirty minims, has been used specifically in the treatment of headaches, other than those due to actual disease of the stomach, as from catarrh or ulceration or cancer. In many forms of headache, and especially the form due to functional gastric derangement, known as "sick headache" it is certainly a serviceable agent."
(Finley Ellingwood: The American Materia Medica, Therapeutics and Pharmacognosy, 1915)